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KMID : 0545120140240091232
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Journal of Microbiology and Biotechnology
2014 Volume.24 No. 9 p.1232 ~ p.1237
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Lycopene-induced hydroxyl radical causes oxidative DNA damage in Escherichia coli
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Lee Won-Young
Lee Dong-Gun
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Abstract
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Lycopene, which is a well-known red carotenoid pigment, has been drawing scientific interest because of its potential biological functions. The current study reports that lycopene acts as a bactericidal agent by inducing reactive oxygen species (ROS)-mediated DNA damage in Escherichia coli. Lycopene treatment elevated the level of ROS―in particular, hydroxyl radicals (˙
OH) ―which can damage DNA in E. coli. Lycopene-induced DNA damage in bacteria was confirmed and we also observed cell filamentation caused by cell division arrest, an indirect marker of the DNA damage repair system, in lycopene-treated E. coli. Increased RecA expression was observed, indicating activation of the DNA repair system (SOS response). To summarize, lycopene exerts its antibacterial effects by inducing ˙OH -mediated DNA damage that cannot be ameliorated by the SOS response. Lycopene may be a clinically useful adjuvant for current antimicrobial therapies.
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KEYWORD
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Lycopene, hydroxyl radical, DNA damage, oxidative stress, Escherichia coli
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